Like all medicines, this medicine can cause side effects, although not everybody gets them. ATPase inhibitor pantoprazole after single intravenous administration. Pantoprazole like other PPIs is well-tolerated. In both studies, pantoprazole sodium for injection 160 or 240 mg per day in divided doses maintained basal acid secretion below target levels in all patients. Pantoprazole sodium for injection contains edetate disodium the salt form of EDTA a chelator of metal ions including zinc. Therefore, zinc supplementation should be considered in patients treated with pantoprazole sodium for injection who are prone to zinc deficiency. Caution should be used when other EDTA containing products are also co-administered intravenously.
Full to partial recovery of these effects were noted in animals of both age groups following a recovery period. Hurlbut KM Eds: POISINDEXR System. MICROMEDEX, Inc. Parenteral routes of administration other than intravenous are not recommended.
Adequate and well-controlled studies in humans have not been done. If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. This study demonstrated that, after 10 days of repeated oral administration followed by 7 days of intravenous administration, the oral and intravenous dosage forms of pantoprazole sodium 40 mg are similar in their ability to suppress MAO and BAO in patients with GERD and a history of erosive esophagitis see Table 3. Also, patients on oral pantoprazole sodium who were switched to intravenous placebo experienced a significant increase in acid output within 48 hours of their last oral dose see Table 3. However, at 48 hours after their last oral dose, patients treated with pantoprazole sodium for injection had a significantly lower mean basal acid output see Table 3 than those treated with placebo.
Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. The active substance in Pantozol Control, pantoprazole, is a proton-pump inhibitor. Continue to take pantoprazole delayed-release tablets even if you feel well. Do not miss any doses.
Approximately 3% of Caucasians and African-Americans and between 17% and 23% of Asians have deficiency of the CYP2C19 hepatic enzyme system, resulting in slow metabolism. Although certain pharmacokinetic values such as half-life and serum concentrations of pantoprazole will be enhanced in these patients, no specific dose adjustments are recommended, and no differences in safety or efficacy are apparent. Use pantoprazole delayed-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions. Acid secretion returns to normal levels without rebound hypersecretion within 1 week. Oral, 40 mg per day for up to eight weeks. An additional eight-week course may be considered in patients who have not healed after four to eight weeks of treatment. After administration of a single intravenous dose of 14C-labeled pantoprazole to healthy, extensive CYP2C19 metabolizers, approximately 71% of the dose was excreted in the urine with 18% excreted in the feces through biliary excretion. There was no renal excretion of unchanged pantoprazole. Not all pack sizes may be marketed. Mycophenolate Mofetil MMF: Administration of pantoprazole 40 mg twice daily for 4 days and a single 1000 mg dose of MMF approximately one hour after the last dose of pantoprazole to 12 healthy subjects in a cross-over study resulted in a 57% reduction in the C max and 27% reduction in the AUC of MPA.
The tablets should be swallowed whole with liquid before a meal and should not be chewed or crushed. How does Pantozol Control work? Black, 19 Hispanic, 52 White were randomized to receive either 40 mg intravenous pantoprazole, 40 mg oral pantoprazole, or placebo once daily for 7 days. Following an overnight fast, test medication was administered and patients were given a light meal within 15 minutes. MAO and BAO were determined 24 hours following the last day of study medication. Following oral or intravenous administration: 1 hour. The usual dose is one tablet a day. Pantoprazole delayed-release tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people. Ask your health care provider any questions you may have about how to use pantoprazole delayed-release tablets. Container: Keep the container tightly closed in order to protect from moisture. Use is not recommended and a decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. The most common side effects with Pantozol Control seen in around 1 patient in 100 are diarrhoea and headache. For the full list of all side effects reported with pantoprazole, see the package leaflet. In one study of gastric pH in healthy subjects, pantoprazole was administered orally 40 mg enteric coated tablets or intravenously 40 mg once daily for 5 days and pH was measured for 24 hours following the fifth dose. For Intravenous Infusion Only. If you have any further questions on the use of this medicine, ask your doctor or pharmacist. Tell your doctor or pharmacist. There are no known symptoms of overdose. Clopidogrel: Clopidogrel is metabolized to its active metabolite in part by CYP2C19. In a crossover clinical study, 66 healthy subjects were administered clopidogrel 300 mg loading dose followed by 75 mg per day alone and with pantoprazole 80 mg at the same time as clopidogrel for 5 days. On Day 5, the mean AUC of the active metabolite of clopidogrel was reduced by approximately 14% geometric mean ratio was 86%, with 90% CI of 79 to 93% when pantoprazole was coadministered with clopidogrel as compared to clopidogrel administered alone. Pharmacodynamic parameters were also measured and demonstrated that the change in inhibition of platelet aggregation induced by 5 µM ADP was correlated with the change in the exposure to clopidogrel active metabolite. furosemide
Pantoprazole is extensively metabolized in the liver through the cytochrome P450 CYP system. Pantoprazole metabolism is independent of the route of administration intravenous or oral. The main metabolic pathway is demethylation, by CYP2C19, with subsequent sulfation; other metabolic pathways include oxidation by CYP3A4. There is no evidence that any of the pantoprazole metabolites have significant pharmacologic activity. An increase in liver enzymes. Pantoprazole is not removed by hemodialysis. In case of overdose, treatment should be symptomatic and supportive. About Memory: “Time of day effects in immediate and delayed memory. Pantoprazole has been associated with a small increase in infectious diarrhoea. Pantoprazole-containing medicines have been available in the European Union EU since 1994. The reference medicine, Pantozol, is only available with a prescription. It is used for long-term treatments and is also used to treat a wider range of gastrointestinal diseases conditions affecting the gut than Pantozol Control. How has Pantozol Control been studied? Timing of elective surgery as a perioperative outcome variable: analysis of pancreaticoduodenectomy. Symptomatic response to therapy with pantoprazole does not preclude the presence of gastric malignancy. Oral, 20 mg once a day in the morning. Dose can be increased to 40 mg once a day in the morning in the case of recurrence. Dosage adjustment of such drugs is not necessary when they are co-administered with pantoprazole. In other in vivo studies, digoxin, ethanol, glyburide, antipyrine, caffeine, metronidazole, and amoxicillin had no clinically relevant interactions with pantoprazole. amda.info esomeprazole
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to and during administration whenever solution and container permit. ECL-cell proliferation and gastric neuroendocrine NE-cell tumors. Gastric NE-cell tumors in rats may result from chronic elevation of serum gastrin concentrations. The high density of ECL cells in the rat stomach makes this species highly susceptible to the proliferative effects of elevated gastrin concentrations produced by proton pump inhibitors. Take the tablets 1 hour before a meal without chewing or breaking them and swallow them whole with some water. Co-administration of pantoprazole in healthy subjects and in transplant patients receiving MMF has been reported to reduce the exposure to the active metabolite, mycophenolic acid MPA possibly due to a decrease in MMF solubility at an increased gastric pH. The clinical relevance of reduced MPA exposure on organ rejection has not been established in transplant patients receiving pantoprazole sodium for injection and MMF. Pantoprazole, by increasing gastric pH, has the potential to affect the bioavailability of any medication for which absorption is pH-dependent. Also, pantoprazole may prevent the degradation of acid-labile drugs. GPT mammalian cell-forward gene mutation assay, the in vitro thymidine kinase mutation test with mouse lymphoma L5178Y cells, and the in vivo rat bone marrow cell chromosomal aberration assay. The incidence rates of adverse reactions were also similar for men and women. European Union EU called Pantozol. What is Pantozol Control used for? It is not known whether pantoprazole is distributed into human breast milk. Pantoprazole and its metabolites are excreted in the milk of rats. Pantoprazole excretion in human milk has been detected in a study of a single nursing mother after a single 40 mg oral dose. The clinical relevance of this finding is not known. Many drugs which are excreted in human milk have a potential for serious adverse reactions in nursing infants. Based on the potential for tumorigenicity shown for pantoprazole in rodent carcinogenicity studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the benefit of the drug to the mother. As an aid to patient consultation, refer to Advice for the Patient, Pantoprazole Systemic. This information should not be used to decide whether or not to take pantoprazole delayed-release tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about pantoprazole delayed-release tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to pantoprazole delayed-release tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using pantoprazole delayed-release tablets. CYP3A4 substrates metoprolol a CYP2D6 substrate diclofenac, naproxen and piroxicam CYP2C9 substrates and theophylline a CYP1A2 substrate in healthy subjects, the pharmacokinetics of pantoprazole were not significantly altered. ECL cell hyperplasia and benign and malignant neuroendocrine cell tumors. Dose selection for this study may not have been adequate to comprehensively evaluate the carcinogenic potential of pantoprazole. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, hands, eyes, throat, or tongue; unusual hoarseness; bloody or watery stools; bone pain; chest pain; fast or irregular heartbeat; fever, chills, or sore throat; red, swollen, blistered, or peeling skin; severe or persistent diarrhea or stomach pain; severe or persistent nausea or vomiting; stomach cramps; symptoms of kidney problems eg, not able to pass urine, change in the amount of urine produced, blood in the urine, a big weight gain; symptoms of liver problems eg, yellowing of the skin or eyes, dark urine, pale stools, nausea, loss of appetite, unusual tiredness; unexplained weight loss; unusual bruising or bleeding; vision changes.
Miller Stage II or III with at least 1 of 3 symptoms typical for reflux esophagitis acid eructation, heartburn, or pain on swallowing were randomized to receive either 40 mg intravenous pantoprazole or 40 mg oral pantoprazole daily for 5 days. After the initial 5 days, all patients were treated with 40 mg oral pantoprazole daily to complete a total of 8 weeks of treatment. Symptom relief was assessed by calculating the daily mean of the sums of the average scores for these 3 symptoms and the daily mean of the average score for each of the symptoms separately. There was no significant difference in symptom relief between pantoprazole sodium for injection and oral pantoprazole sodium therapy within the first 5 days. A repeat endoscopy after 8 weeks of treatment revealed that 20 out of 23 87% of the pantoprazole sodium for injection plus oral pantoprazole sodium patients and 19 out of 22 86% of the oral pantoprazole sodium patients had endoscopically proven healing of their esophageal lesions. Do not stop taking these tablets without first talking to your doctor or pharmacist. Adverse events seen in spontaneous reports of overdose generally reflect the known safety profile of pantoprazole. Mild, transient transaminase elevations have been observed in clinical studies. The clinical significance of this finding in a large population of subjects administered intravenous pantoprazole is unknown. No differences in efficacy or safety between men and women are apparent. This may not be a complete list of all interactions that may occur. Ask your health care provider if pantoprazole delayed-release tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. The 20 mg gastro-resistant tablets are light brownish yellow, oval, slightly biconvex tablets. CDAD. A diagnosis of CDAD should be considered for patients taking PPIs who develop diarrhea that does not improve. The FDA is working with manufacturers to include information about the increased risk of CDAD with use of PPIs in the drug labels. FDA is also reviewing the risk of CDAD in users of histamine H2 receptor blockers. Pantoprazole. Remember to also mention any other ill-effects like pain in your joints. can you buy imuran under 18
If you have ever had a skin reaction after treatment with a medicine similar to Pantoprazole that reduces stomach acid. US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. Intravenous infusion, 40 mg at a rate of 3 mg 7 mL per minute over approximately fifteen minutes each day for seven to ten days. Patients in whom intentional overdose is confirmed or suspected should be referred for psychiatric consultation. Caucasians and African-Americans and 17 to 23% of Asians. If you experience side effects like dizziness or disturbed vision, you should not drive or operate machines. The symptoms of acute toxicity were hypoactivity, ataxia, hunched sitting, limb-splay, lateral position, segregation, absence of ear reflex, and tremor. Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenia. Appropriate studies on the relationship of age to the effects of pantoprazole have not been performed in the pediatric population. Safety and efficacy have not been established. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. In the treatment of gastroesophageal reflux disease and gastric ulcer, relief of symptoms usually occurs within 2 weeks and healing within 4 weeks. Therapy should not exceed 8 weeks. Controlled studies of pantoprazole used as maintenance therapy to prevent reflux esophagitis recurrence have not been conducted beyond 12 months, although in a limited number of patients have received continuous maintenance treatment for up to 8 years. In the treatment of duodenal ulcer, relief of symptoms usually occurs within 1 week and healing within 2 weeks. Therapy should not exceed 4 weeks. If your symptoms do not improve or if they become worse, check with your doctor. discount eulexin online
Pantoprazole sodium for injection 40 mg once daily does not raise gastric pH to levels sufficient to contribute to the treatment of such life-threatening conditions. Rockville, MD, 1998. p 548. Pantoprazole delayed-release tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get pantoprazole delayed-release tablets refilled. The placebo group showed a sustained, continuous acid output for 25 hours, validating the reliability of the testing model. Pantoprazole sodium for injection had an onset of antisecretory activity within 15 to 30 minutes of administration. Doses of 20 to 80 mg of pantoprazole sodium for injection substantially reduced the 24-hour cumulative PSAO in a dose-dependent manner, despite a short plasma elimination half-life. Complete suppression of PSAO was achieved with 80 mg within approximately 2 hours and no further significant suppression was seen with 120 mg. The duration of action of pantoprazole sodium for injection was 24 hours. Pantoprazole delayed-release tablets should be used with caution in Asian patients; the risk of side effects may be increased in these patients. Pantoprazole may stop these and other medicines from working properly. The medicine can be obtained without a prescription. How is Pantozol Control used?
Pue MA, Laroche J, Meineke I et al: Pharmacokinetics of pantoprazole following single intravenous and oral administration to healthy male subjects. What are the side effects of pantoprazole? Therefore, it is important to use the lowest doses and shortest duration of treatment necessary for the condition being treated. In a 5-day study of oral pantoprazole with 40 and 60 mg doses in healthy subjects, following the last dose on day 5, median 24-hour serum gastrin concentrations were elevated by 3 to 4 fold compared to placebo in both 40 and 60 mg dose groups. However, by 24 hours following the last dose, median serum gastrin concentrations for both groups returned to normal levels. Pantoprazole is indicated for the prevention of relapse in patients with reflux esophagitis. Pantoprazole, in combination with clarithromycin and either amoxicillin or metronidazole, is indicated for treatment of patients with an active duodenal ulcer who are H. pylori positive. The clinical significance of this finding is not clear. Pantoprazole delayed-release tablets may increase the risk of a serious form of diarrhea. Contact your doctor right away if stomach pain or cramps, severe or persistent diarrhea, or bloody or watery stools occur. Discuss any questions or concerns with your doctor. Is pantoprazole available as a generic drug? Sodium Chloride Injection, USP. Pantoprazole is metabolized mainly by CYP2C19 and to minor extents by CYPs 3A4, 2D6 and 2C9. pharmacy online cymbalta generic
Transition from oral to intravenous and from intravenous to oral formulations of gastric acid inhibitors should be performed in such a manner to ensure continuity of effect of suppression of acid secretion. Patients with Zollinger-Ellison Syndrome may be vulnerable to serious clinical complications of increased acid production even after a short period of loss of effective inhibition. Inside Science: “Time of Day Could Impact Athletes' Performance Peak. Significantly different from pantoprazole sodium for injection. If you miss a dose of pantoprazole delayed-release tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Suerbaum S, Leying H, Klemm K et al: Antibacterial activity of pantoprazole and omeprazole against Heliobacter pylori. pamelor
Animal studies have demonstrated that pantoprazole crosses the placental barrier; however, no teratogenic effects were observed. Doses of 15 mg per kg resulted in delayed fetal skeletal development. If you have reduced body stores or risk factors for reduced vitamin B12 and receive pantoprazole long-term treatment. American Council on Exercise: “The Best Time to Exercise. Although no significant drug-drug interactions have been observed in clinical studies, the potential for significant drug-drug interactions with more than once daily dosing with high doses of pantoprazole has not been studied in poor metabolizers or individuals who are hepatically impaired. The recommended dose of Pantozol Control is one tablet once a day until symptoms have stopped. The patient may need to take the medicine for two to three days in a row for symptoms to improve. If there is no improvement in symptoms within two weeks of continuous treatment, patients should consult their doctor. Patients should not take the medicine for longer than four weeks without consulting their doctor. Gas; headache; joint pain; mild diarrhea or stomach pain; nausea; symptoms of upper respiratory tract infection eg, cough, runny or stuffy nose, sneezing in children; vomiting. After first opening of the container, the product should be used within 3 months. Do NOT change your dose, stop taking pantoprazole delayed-release tablets, or take pantoprazole delayed-release tablets for longer than prescribed without checking with your doctor. Tablets may be taken before, during, or following the morning meal. Neither food nor antacids altered the bioavailability of pantoprazole.
Pantoprazole is a proton pump inhibitor. It accumulates in the acidic compartment of parietal cells and is converted to the active form, a sulfanilamide, which binds to hydrogen-potassium-ATP-ase at the secretory surface of gastric parietal cells. Inhibition of hydrogen-potassium-ATP-ase blocks the final step of gastric acid production, leading to inhibition of both basal and stimulated acid secretion. The duration of inhibition of acid secretion does not correlate with the much shorter elimination half-life of pantoprazole. Use pantoprazole delayed-release tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially hip, wrist, and spine fractures. Pantoprazole sodium for injection is indicated for the treatment of pathological hypersecretory conditions including Zollinger-Ellison Syndrome in adults. Concomitant use of atazanavir or nelfinavir with proton pump inhibitors is not recommended. Co-administration of atazanavir or nelfinavir with proton pump inhibitors is expected to substantially decrease atazanavir or nelfinavir plasma concentrations and may result in a loss of therapeutic effect and development of drug resistance. The active substance is pantoprazole. The data from these studies revealed that animals in both age groups respond to pantoprazole in a similar manner. An increased incidence of thyroid tumor in rats, although within the historical ranges for the strain tested, was observed following exposure to pantoprazole 200 mg per kg daily. Pantoprazole-induced liver enzyme induction results in increased metabolism of thyroid hormone, leading in turn to increased production of TSH, with subsequent increased trophic changes within the thyroid gland. No similar effects have been observed in humans following exposure to usual clinical doses. Do not use this medicine after the expiry date which is stated on the packaging after EXP. Pantoprazole sodium for injection is indicated for short-term treatment 7 to 10 days of adult patients with gastroesophageal reflux disease GERD and a history of erosive esophagitis. The incidence rates of adverse events and laboratory abnormalities in patients aged 65 years and older were similar to those associated with patients younger than 65 years of age. SD rats after 17 months, most likely due to elevated gastrin levels during chronic therapy. ECL-cell neoplasms did not occur over 24 months observations in mice receiving 5, 25, or 150 mg per kg daily. Kaplan B: Proton pump inhibitors: new drugs and indications. olmesartan
Pantoprazole was more effective than placebo and ranitidine at improving the symptoms of acid reflux. In the first study, 74% of the patients taking pantoprazole 80 out of 108 and 43% of those taking placebo 48 out of 111 had no heartburn after two weeks. Pantoprazole was also more effective than placebo at reducing symptoms of acid regurgitation. In the second study, 70% of the patients taking pantoprazole 121 out of 172 and 59% of those talking ranitidine 102 out of 172 had no heartburn after two weeks of treatment. What is the risk associated with Pantozol Control? The dosage of pantoprazole sodium for injection in patients with pathological hypersecretory conditions including Zollinger-Ellison Syndrome varies with individual patients. The recommended adult dosage is 80 mg intravenously every 12 hours. The frequency of dosing can be adjusted to individual patient needs based on acid output measurements. Pantoprazole sodium for injection is supplied as a sterile, freeze-dried, white to off-white, porous cake or powder containing 40 mg of pantoprazole per vial. Hematologic: leukopenia reported in ex-U. Pantoprazole delayed-release tablets may increase the risk of hip, wrist, and spine fractures in patients with weak bones osteoporosis. The risk may be greater if you use pantoprazole delayed-release tablets in high doses or for longer than a year, or if you are older than 50 years old. Contact your doctor if you have any questions about this information. Pantozol Control is used for the short-term treatment of the symptoms of acid reflux in adults. Acid reflux is when acid produced in the stomach escapes into the gullet, causing heartburn and acid regurgitation acid flowing up into the mouth. Diabetes Forecast: “Does It Matter When You Exercise? There have been reports of excretion into human breast milk. The CHMP noted that pantoprazole 20 mg was effective in the short-term treatment of reflux symptoms and that there is a long safety experience with the medicine as a prescription medicine. It was also of the opinion that, based on the experience of the use of pantoprazole, the availability of Pantozol Control without medical supervision is appropriate. Check with your doctor to see whether you should take a calcium and vitamin D supplement while you use pantoprazole delayed-release tablets. Study 1 was a multicenter, double-blind, placebo-controlled, study of the pharmacodynamic effects of pantoprazole sodium for injection and oral pantoprazole sodium. Store pantoprazole delayed-release tablets at room temperature, between 68 and 77 degrees F 20 and 25 degrees C. Store away from heat, moisture, and light. Do not store in the bathroom. Keep pantoprazole delayed-release tablets out of the reach of children and away from pets.
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There have been postmarketing reports of increased INR and prothrombin time in patients receiving proton pump inhibitors, including pantoprazole, and warfarin concomitantly. Increases in INR and prothrombin time may lead to abnormal bleeding and even death. Patients treated with proton pump inhibitors and warfarin concomitantly should be monitored for increases in INR and prothrombin time. Do not take a double dose to make up for a forgotten dose. Take your next normal dose at the usual time. H-benzimidazole, a compound that inhibits gastric acid secretion. Its molecular formula is C 16H 14F 2N 3NaO 4S, with a molecular weight of 405.
There have been reports of false positive urine screening tests for tetrahydrocannabinol THC in patients receiving proton pump inhibitors including pantoprazole. An alternative confirmatory method should be considered to verify positive results. All medicines may cause side effects, but many people have no, or minor, side effects. Methotrexate a chemotherapy medicine used in high doses to treat cancer. Oral, 40 mg per day for up to four weeks. Product Information: Pantoloc, pantoprazole. Solvay Pharma, Ontario, Canada.
Keep this leaflet. You may need to read it again. The reconstituted solution may be stored for up to 2 hours at room temperature prior to further dilution. The admixed solution may be stored for up to 12 hours at room temperature prior to administration. Pantoprazole is a selective “proton pump inhibitor”, a medicine which reduces the amount of acid produced in your stomach. Long-term treatment eg, longer than 3 years with medicines like this one has rarely caused low vitamin B12 levels. Discuss any questions or concerns with your doctor. You may take antacids while you are using pantoprazole delayed-release tablets if you are directed to do so by your doctor.
It is used for treating acid-related diseases of the stomach and intestine. It is recommended that pantoprazole, after reconstitution and admixture, be administered through a separate line, by itself, and without mixing with other intravenous fluids or medications. The in-line filter provided with the medication must be used to remove the precipitates that may form when the reconstituted solution is mixed with intravenous solutions. Pantoprazole delayed-release tablets are indicated for the short-term up to 8 weeks treatment of heartburn and other symptoms associated with GERD. Pantoprazole for injection is indicated for the short-term 7 to 10 days treatment of GERD in patients who are unable to continue taking pantoprazole delayed-release tablets. Pantoprazole for injection is not indicated for initial treatment of GERD.